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CAS NO: 796073-69-3
Molecular Formula: C38H54ClN3O10S
Molecular Weight: 780.36700
EINECS NO: 641-067-1
MDL NO: NA
Product Description:
Product Name: N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4) CAS NO: 796073-69-3
Synonyms:
Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-;DM4 top3;
Mertansine Impurity 1;
N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4);
Chemical Physical Properties:
Appearance: Powder
Assay : Greater than or equal to 99.0 percent
Density: 1.29±0.1 g/cm3(Predicted)
Melting Point: 185-187 degree (decomp)
Boiling Point: 943.2±65.0 degree (Predicted)
Pka: 9.82±0.70(Predicted)
Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs).M4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.
N2''-Deacetyl-N2''-(4-mercapto-4-methyl-1-oxopentyl)-maytansine is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.
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